Your genes play an important role

Your genes play an important role

There is a question I often hear when I first talk to someone about environmental illness or mold toxicity: "Why do I have this and not my husband if we live together since 25 years and have more or less the same routines?".

He is from another family and you too! Your genetics are totally different, even if you love each other! But which ones are the genes responsible for this kind of illness?

There is a list of genes responsible for beiing more susceptible for different health issues. We all know about it. It is the same with mold toxicity. I will explain which genes could explain your situation:

HLA-DR and HLA-DQ genes, which influence the immune response to mycotoxins, as well as genes involved in cellular detoxification like Nrf2 and the CYP450 family. Genetic variations in these and other genes, like MTHFR, can impair the body's ability to eliminate toxins or mount an appropriate immune response, leading to heightened sensitivity and chronic health issues.

Immune Response Genes

• HLA (Human Leukocyte Antigen) Genes: Variations in the HLA-DR and HLA-DQ genes are strongly linked to an increased risk of mold-related health issues. These genes control how the immune system recognizes and responds to foreign substances, and certain variants can lead to an overactive or inefficient immune response to molds and their toxins.

• Detoxification Genes

  • Nrf2 Pathway: Nrf2 is a central regulator of the antioxidant response and plays a crucial role in the body's defense against mycotoxins.

  • CYP450 Gene Family: These genes are responsible for Phase I detoxification, metabolizing toxins to make them more reactive and easier for the body to excrete.

  • Phase II & III Detoxification Genes: Genes encoding enzymes for Phase II (e.g., UGT, GST) and transport proteins for Phase III are crucial for conjugating toxins and excreting them from the body.

  Other Related Genes

  • MTHFR Gene: Mutations in the MTHFR gene can affect the methylation process, which is an important aspect of detoxification and overall health.

  • ADAD1 and IL2 Genes: Research has linked single nucleotide polymorphisms (SNPs) in these genes to increased susceptibility to various allergies, including potential mold allergies.

Now you can ask yourself how you can discover if you have those genes or some of them. The other question is if you have both TT, TC or CC alleles, which would influence if you are protected from your genes, or you are a mixture type and you are then half-susceptible, or if you are very susceptible because you have both alleles which make you be unprotected to those environmental toxins.

There are very simple saliva gen tests you can run at home and send to the laboratory. After 8 weeks you will become a full report with your genetic expression.

Knowing about your genes will help you take decisions: Which medication, which foods and which lifestyle decisions you take.

And also it would help you know how your environment influences you and if you could have health issues because of external toxins.

Do you want to have a look at your genetic expression with me?